fis_lib_measure/lib/process/calcuators/formulas/cardiac.dart

import 'dart:math' as math;

import 'package:fis_measure/configs/cardiac.dart';
import 'package:fis_measure/configs/patient.dart';
import 'package:fis_measure/interfaces/enums/species.dart';
import 'package:fis_measure/process/calcuators/formulas/general.dart';
import 'package:fis_measure/utils/number.dart';

class CardiacFormulas {
  static ICardiacFormulaStrategy _singleton = AnimalsCardiacFormulas();
  static void reinitialize() {
    if (GlobalPatientConfig.speciesType == SpeciesType.mouse) {
      GlobalCardiacConfigs.density = 1.05;
      _singleton = MouseCardiacFormulas();
    } else {
      GlobalCardiacConfigs.density = 1.04;
      _singleton = AnimalsCardiacFormulas();
    }
  }

  static double teiIndex(double co, double et) => _singleton.teiIndex(co, et);
  static double ef(double edv, double esv) => _singleton.ef(edv, esv);
  static double edvTeichholz(double lvidd) => _singleton.edvTeichholz(lvidd);
  static double edvCube(double lvidd) => _singleton.edvCube(lvidd);
  static double esvTeichholz(double lvids) => _singleton.esvTeichholz(lvids);
  static double esvCube(double lvids) => _singleton.esvCube(lvids);
  static double sv(double edv, double esv) => _singleton.sv(edv, esv);
  static double co(double sv, {required int hr}) => _singleton.co(sv, hr: hr);
  static double ci(double sv, {required int hr, required double bsa}) =>
      _singleton.ci(sv, hr: hr, bsa: bsa);
  static double lvdMass(double ivsd, double lvidd, double lvpwd) =>
      _singleton.lvdMass(ivsd, lvidd, lvpwd);
  static double lvdMassAL(
          double lvadSaxEpi, double lvadSaxEndo, double lvldApical) =>
      _singleton.lvdMassAL(lvadSaxEpi, lvadSaxEndo, lvldApical);
  static double lvdMassIndex(double lvdmass, double bsa) =>
      _singleton.lvdMassIndex(lvdmass, bsa);
  static double fsPercent(double lvidd, double lvids) =>
      _singleton.fsPercent(lvidd, lvids);
  static double ivsPercent(double ivss, double ivsd) =>
      _singleton.ivsPercent(ivss, ivsd);
  static double lvpwPercent(double lvpws, double lvpwd) =>
      _singleton.lvpwPercent(lvpws, lvpwd);
  static double mamPercent(double mapse, double lvidd, double lvids) =>
      _singleton.mamPercent(mapse, lvidd, lvids);
  static double si(double sv, double bsa) => _singleton.si(sv, bsa);
  static double flowAreaByVTI(double otDiam, double otvti, double vti) =>
      _singleton.flowAreaByVTI(otDiam, otvti, vti);
  static double dviByVTI(double otvti, double vti) =>
      _singleton.dviByVTI(otvti, vti);
  static double avaIndex(double avaByVTI, double bsa) =>
      _singleton.avaIndex(avaByVTI, bsa);
  static double lvevi(double lvev, double bsa) => _singleton.lvevi(lvev, bsa);
  static double lvSimsonVolume(double l, List<double>? a, List<double>? b,
          [int num = 20]) =>
      _singleton.lvSimsonVolume(l, a, b, num);

  static double mrEROA(double mrRadius, double mrAlsVel, double mrVmax) =>
      _singleton.mrEROA(mrRadius, mrAlsVel, mrVmax);
  static double mrRV(double mrEROA, double mrVti) =>
      _singleton.mrRV(mrEROA, mrVti);
  static double mrFlowRate(double mrRadius, double mrAlsVel) =>
      _singleton.mrFlowRate(mrRadius, mrAlsVel);

  static double lvidIndex(double lvid, double bsa) =>
      _singleton.lvidIndex(lvid, bsa);
  static double lvidN(double lvid, double weight) =>
      _singleton.lvidN(lvid, weight);

  // CardiacFormulas._internal(); // 私有构造函数

  static double bsa(double weight) {
    return 0.1 * math.pow(weight, 0.667);
  }
}

abstract class ICardiacFormulaStrategy {
  double teiIndex(double co, double et);
  double ef(double edv, double esv);
  double edvTeichholz(double lvidd);
  double edvCube(double lvidd);
  double esvTeichholz(double lvids);
  double esvCube(double lvids);
  double sv(double edv, double esv);
  double co(double sv, {required int hr});
  double ci(double sv, {required int hr, required double bsa});
  double lvdMass(double ivsd, double lvidd, double lvpwd);
  double lvdMassAL(double lvadSaxEpi, double lvadSaxEndo, double lvldApical);
  double lvdMassIndex(double lvdmass, double bsa);
  double fsPercent(double lvidd, double lvids);
  double ivsPercent(double ivss, double ivsd);
  double lvpwPercent(double lvpws, double lvpwd);
  double mamPercent(double mapse, double lvidd, double lvids);
  double si(double sv, double bsa);
  double flowAreaByVTI(double otDiam, double otvti, double vti);
  double dviByVTI(double otvti, double vti);
  double avaIndex(double avaByVTI, double bsa);
  double lvevi(double lvev, double bsa);
  double lvSimsonVolume(double l, List<double>? a, List<double>? b,
      [int num = 20]);

  double mrEROA(double mrRadius, double mrAlsVel, double mrVmax);
  double mrRV(double mrEROA, double mrVti);
  double mrFlowRate(double mrRadius, double mrAlsVel);

  /// LVID Index
  ///
  /// [lvid] cm
  ///
  /// [bsa] m2
  double lvidIndex(double lvid, double bsa);

  /// LVID N
  ///
  /// [lvid] cm
  ///
  /// [weight] kg
  double lvidN(double lvid, double weight);
}

/// 基础公式
class BaseCardiacFormulas implements ICardiacFormulaStrategy {
  /// IMP
  ///
  /// Formula: `(CO-ET)/ET`
  ///
  /// Result Unit: `None`
  @override
  double teiIndex(double co, double et) {
    double imp = 0.0;
    if (et != 0.0) {
      imp = (((co).abs() - (et).abs()) / et).abs();
    }
    return imp;
  }

  /// EF
  /// Formula: `(EDV - ESV )/EDV`
  ///
  /// [edv] Unit: `cm³`
  ///
  /// [esv] Unit: `cm³`
  ///
  /// Result Unit: `None`
  @override
  double ef(double edv, double esv) {
    // 这行判断暂时注释掉是为了使实际表现与旧版一致
    // if (edv < esv) {
    //   return double.nan;
    // }
    return (edv - esv) / edv * 100;
  }

  /// EDV (Teichholz)
  ///
  ///  Formula: `[7.0/(2.4 + LVIDd)] x LVIDd^3`
  ///
  /// [lvidd] Unit: `cm`
  ///
  /// Result Unit: `cm³`
  @override
  double edvTeichholz(double lvidd) {
    double edv = double.nan;
    if (!NumUtil.almostEquals(lvidd, 0)) {
      edv = 7.0 * math.pow(lvidd, 3) / (2.4 + lvidd);
    }
    return edv;
  }

  /// EDV (Cube)
  ///
  ///  Formula: `LVIDd^3`
  ///
  /// [lvidd] Unit: `cm`
  ///
  /// Result Unit: `cm³`
  @override
  double edvCube(double lvidd) {
    double edv = double.nan;
    if (!NumUtil.almostEquals(lvidd, 0)) {
      edv = math.pow(lvidd, 3).toDouble();
    }
    return edv;
  }

  /// ESV (Teichholz)
  ///
  ///  Formula: `[7.0/(2.4 + LVIDs)] x LVIDs^3`
  ///
  /// [lvids] Unit: `cm`
  ///
  /// Result Unit: `cm³`
  @override
  double esvTeichholz(double lvids) {
    // 计算公式相同，入参不同
    return edvTeichholz(lvids);
  }

  /// ESV (Cube)
  ///
  ///  Formula: `LVIDs^3`
  ///
  /// [lvids] Unit: `cm`
  ///
  /// Result Unit: `cm³`
  @override
  double esvCube(double lvids) {
    // 计算公式相同，入参不同
    return edvCube(lvids);
  }

  /// SV
  @override
  double sv(double edv, double esv) {
    return edv - esv;
  }

  /// CO
  @override
  double co(
    double sv, {
    required int hr,
  }) {
    return (sv - hr) / 1000.0;
  }

  /// CI
  @override
  double ci(
    double sv, {
    required int hr,
    required double bsa,
  }) {
    return ((sv - hr) / 1000.0) / bsa;
  }

  /// <summary>
  /// LVEVI = LVEV / BSA
  /// </summary>
  /// <param name="lvev">Unit cm³</param>
  /// <param name="bsa">Unit m²</param>
  /// <returns>cm³/m²</returns>
  @override
  double lvevi(double lvev, double bsa) {
    return lvev / bsa;
  }

  /// LVdMass
  /// LVd Mass(2D)
  @override
  double lvdMass(double ivsd, double lvidd, double lvpwd) {
    final density = GlobalCardiacConfigs.density;
    double part1 = math.pow(ivsd + lvidd + lvpwd, 3).toDouble();
    double part2 = math.pow(lvidd, 3).toDouble();
    double value = (density * (part1 - part2)) / 1000.0;
    return value;
  }

  /// LVd Mass AL
  @override
  double lvdMassAL(
    double lvadSaxEpi,
    double lvadSaxEndo,
    double lvldApical,
  ) {
    double t =
        math.sqrt(lvadSaxEpi / math.pi) - math.sqrt(lvadSaxEndo / math.pi);
    double mass = 1.05 *
        5 /
        6 *
        (lvadSaxEpi * (lvldApical + t) - lvadSaxEndo * lvldApical) /
        1000;
    return mass;
  }

  /// LVd Mass Index
  @override
  double lvdMassIndex(double lvdmass, double bsa) {
    return lvdmass / bsa * 1000;
  }

  /// %FS
  @override
  double fsPercent(double lvidd, double lvids) {
    return ((lvidd - lvids) / lvidd) * 100;
  }

  /// %IVS
  @override
  double ivsPercent(double ivss, double ivsd) {
    return ((ivss - ivsd) / ivsd) * 100;
  }

  /// %LVPW
  @override
  double lvpwPercent(double lvpws, double lvpwd) {
    return ((lvpws - lvpwd) / lvpwd) * 100;
  }

  /// MAM%
  @override
  double mamPercent(double mapse, double lvidd, double lvids) {
    return mapse / (lvidd - lvids + mapse) * 100;
  }

  /// SI
  ///
  /// (EDV - ESV)/BSA
  ///
  /// [sv] cm³
  ///
  /// [bsa] m²
  ///
  /// return `cm³/m²`
  @override
  double si(double sv, double bsa) {
    double si = sv / bsa;
    return si;
  }

  /// <summary>
  /// <para>MVA VTI = 1/4 x π x (LVOT Diam)^2 x LVOT VTI/MV VTI </para>
  /// <para>AVA VTI = 1/4 x π x (LVOT Diam)^2 x LVOT VTI/AV VTI</para>
  /// <para>TVA VTI = 1/4 x π x (RVOT Diam)^2 x RVOT VTI/TV VTI</para>
  /// <para>PVA VTI = 1/4 x π x (RVOT Diam)^2 x RVOT VTI/PV VTI</para>
  /// </summary>
  /// <param name="otDiam">cm</param>
  /// <param name="otvti">cm</param>
  /// <param name="vti">cm</param>
  /// <returns>cm^2</returns>
  @override
  double flowAreaByVTI(double otDiam, double otvti, double vti) {
    double sv = 0.25 * math.pi * math.pow(otDiam, 2) * otvti / vti;
    return sv;
  }

  /// <param name="otvti">cm</param>
  /// <param name="vti">cm</param>
  /// <returns>Unit None</returns>
  @override
  double dviByVTI(double otvti, double vti) {
    double dvi = double.nan;
    if (!GeneralFormulas.doubleAlmostEquals(vti, 0)) {
      dvi = otvti / vti;
    }
    return dvi;
  }

  /// <summary>
  /// AVA Index = avaByVTI/bsa
  /// </summary>
  /// <param name="avaByVTI">cm2</param>
  /// <param name="bsa">m2</param>
  /// <returns>cm2/m2</returns>
  @override
  double avaIndex(double avaByVTI, double bsa) {
    double index = double.nan;
    if (!GeneralFormulas.doubleAlmostEquals(bsa, 0)) {
      index = avaByVTI / bsa;
    }
    return index;
  }

  /// <summary>
  /// Formular : V= π/4×∑_(i=1)^20▒〖(a_i×b_i)〗×L/20
  /// </summary>
  /// <returns></returns>
  @override
  double lvSimsonVolume(double l, List<double>? a, List<double>? b,
      [int num = 20]) {
    double volume = double.nan;
    if (a != null && b != null) {
      double sum = 0;
      for (int i = 0; i < num; i++) {
        sum += a[i] * b[i] * l / num;
      }
      volume = math.pi / 4 * sum;
    }

    return volume;
  }

  @override
  double mrEROA(double mrRadius, double mrAlsVel, double mrVmax) {
    double mrEROA = double.nan;
    if (!GeneralFormulas.doubleAlmostEquals(mrVmax, 0)) {
      mrEROA = 2 * math.pi * math.pow(mrRadius, 2) * mrAlsVel / (mrVmax).abs();
    }
    return mrEROA;
  }

  @override
  double mrRV(double mrEROA, double mrVti) {
    return mrEROA * mrVti;
  }

  @override
  double mrFlowRate(double mrRadius, double mrAlsVel) {
    double flowRate = 2 * math.pi * math.pow(mrRadius, 2) * mrAlsVel;
    return flowRate;
  }

  @override
  double lvidIndex(double lvid, double bsa) {
    // [LVIDd|Distance"cm;2D"]/[BSA"m2;PatientInfo"]
    double value = lvid / bsa;
    return value;
  }

  @override
  double lvidN(double lvid, double weight) {
    // [LVIDs|Distance"cm;2D"]/pow([Weight"kg;PatientInfo"],0.294)
    double value = lvid / math.pow(weight, 0.294);
    return value;
  }
}

/// 实验室小鼠
class MouseCardiacFormulas extends BaseCardiacFormulas {
  MouseCardiacFormulas() : super();
}

/// 人用普通公式
class AnimalsCardiacFormulas extends BaseCardiacFormulas {
  AnimalsCardiacFormulas() : super();

  // @override
  // double edvTeichholz(double lvidd) {
  //   double edv = double.nan;
  //   double animalsLvidd = lvidd / 10;
  //   if (!NumUtil.almostEquals(animalsLvidd, 0)) {
  //     edv = 7.0 * math.pow(animalsLvidd, 3) / (2.4 + animalsLvidd);
  //   }
  //   return edv;
  // }

  /// CO
  @override
  double co(
    double sv, {
    required int hr,
  }) {
    return (sv - hr);
  }

  /// CI
  @override
  double ci(
    double sv, {
    required int hr,
    required double bsa,
  }) {
    return ((sv - hr)) / bsa;
  }

  /// ESV (Teichholz)
  ///
  ///  Formula: `[7.0/(2.4 + LVIDs)] x LVIDs^3`
  ///
  /// [lvids] Unit: `cm`
  ///
  /// Result Unit: `cm³`
  @override
  double esvTeichholz(double lvids) {
    // 计算公式相同，入参不同
    return edvTeichholz(lvids);
  }

  /// <summary>
  /// <para>MVA VTI = 1/4 x π x (LVOT Diam)^2 x LVOT VTI/MV VTI </para>
  /// <para>AVA VTI = 1/4 x π x (LVOT Diam)^2 x LVOT VTI/AV VTI</para>
  /// <para>TVA VTI = 1/4 x π x (RVOT Diam)^2 x RVOT VTI/TV VTI</para>
  /// <para>PVA VTI = 1/4 x π x (RVOT Diam)^2 x RVOT VTI/PV VTI</para>
  /// </summary>
  /// <param name="otDiam">cm</param>
  /// <param name="otvti">cm</param>
  /// <param name="vti">cm</param>
  /// <returns>cm^2</returns>
  /// SV(LVOT)|CO
  @override
  double flowAreaByVTI(double otDiam, double otvti, double vti) {
    double animalsOtDiam = otDiam / 10;
    double animalsOtvti = otvti / 10;
    double animalsVti = vti / 10;
    double sv =
        0.25 * math.pi * math.pow(animalsOtDiam, 2) * animalsOtvti / animalsVti;
    return sv;
  }

  @override
  double lvdMass(double ivsd, double lvidd, double lvpwd) {
    final density = GlobalCardiacConfigs.density;
    const correctionFactor = GlobalCardiacConfigs.correctionFactor;
    double part1 = math.pow(ivsd + lvidd + lvpwd, 3).toDouble();
    double part2 = math.pow(lvidd, 3).toDouble();
    double value = ((density * part1 - part2) + correctionFactor) / 1000.0;
    return value;
  }
}